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Invitrogen
CHMP2A Polyclonal Antibody
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FIGURE: 1 / 2
CHMP2A Antibody (PA5-119777) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded rat bladder tissue using CHMP2A Polyclonal Antibody (Product # PA5-119777). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the CHMP2A antibody at a dilution of... View More
Product Details
PA5-119777
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within N-terminal human CHMP2A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: SW480 cell lysate, A431 cell lysate, HepG2 cell lysate, rat bladder tissue.
Subcellular Location: Late endosome membrane.
Target Information
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A is required for both MVB formation and regulation of cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BC-2; BC-2; 32 kDa; Charged multivesicular body protein 2a; CHMP2a; chromatin modifying protein 2A; Chromatin-modifying protein 2a; mVps2; p32; putative breast adenocarcinoma marker; putative breast adenocarcinoma marker (32kD); Putative breast adenocarcinoma marker BC-2; unnamed protein product; Vacuolar protein sorting-associated protein 2; Vacuolar protein sorting-associated protein 2-1; vacuolar protein-sorting-associated protein 2; VPS2 homolog A; Vps2-1
Gene Aliases: 1500016L11Rik; BC-2; BC2; CHMP2; CHMP2A; RGD1305050; VPS2; VPS2A
UniProt ID: (Human) O43633, (Mouse) Q9DB34
Entrez Gene ID: (Human) 27243, (Rat) 365191, (Mouse) 68953
plasma membrane repair
autophagy
nucleus organization
vacuolar transport
mitotic metaphase plate congression
membrane invagination
exit from mitosis
regulation of centrosome duplication
protein transport
macroautophagy
viral release from host cell
nuclear envelope reassembly
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
establishment of protein localization
late endosome to vacuole transport
viral budding from plasma membrane
protein polymerization
protein homooligomerization
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
positive regulation of exosomal secretion
negative regulation of centriole elongation
ESCRT III complex disassembly
cell separation after cytokinesis
regulation of viral process
protein heterooligomerization
negative regulation of cell death
positive regulation of viral release from host cell
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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