Search

  • Contact Us
  • Quick Order

Invitrogen

Epo Polyclonal Antibody

View all (36) Epo antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

PA5-120937

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.34 mg/mL

Amount

234 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914509

Product Specific Information

Positive test controls include: Mouse liver. The target is usually found in the following locations: Secreted.

Target Information

Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: epoetin; Erythropoietin; MGC138142; unnamed protein product

View more View less

Gene Aliases: DBAL; ECYT5; EP; EPO; MVCD2

View more View less

UniProt ID: (Human) P01588, (Mouse) P07321, (Rat) P29676

View more View less

Entrez Gene ID: (Human) 2056, (Mouse) 13856, (Rat) 24335

View more View less

Function(s)
cytokine activity erythropoietin receptor binding hormone activity protein binding protein kinase activator activity
Process(es)
angiogenesis response to hypoxia heart morphogenesis regulation of transcription from RNA polymerase II promoter apoptotic process embryo implantation positive regulation of cell proliferation negative regulation of calcium ion transport into cytosol peptidyl-serine phosphorylation erythrocyte differentiation negative regulation of myeloid cell apoptotic process positive regulation of tyrosine phosphorylation of Stat5 protein hemoglobin biosynthetic process negative regulation of apoptotic process erythrocyte maturation positive regulation of neuron differentiation positive regulation of DNA replication positive regulation of protein kinase activity positive regulation of transcription, DNA-templated positive regulation of Ras protein signal transduction cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis vasculogenesis involved in coronary vascular morphogenesis visceral serous pericardium development cellular hyperosmotic response negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress negative regulation of erythrocyte apoptotic process negative regulation of cation channel activity negative regulation of transcription from RNA polymerase II promoter response to stress acute-phase response signal transduction response to nutrient blood circulation response to salt stress positive regulation of neuron projection development response to lipopolysaccharide myeloid cell apoptotic process response to vitamin A response to testosterone erythropoietin-mediated signaling pathway positive regulation of activated T cell proliferation proteasome-mediated ubiquitin-dependent protein catabolic process response to estrogen response to axon injury response to electrical stimulus response to hyperoxia positive regulation of ERK1 and ERK2 cascade response to interleukin-1 response to dexamethasone receptor signaling pathway via STAT aging
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support