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Invitrogen
BSEP Polyclonal Antibody
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FIGURE: 1 / 2
BSEP Antibody (PA5-13105) in IHC (P)
Immunohistochemistry analysis of ABCB11 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with ABCB11 polyclonal antibody (Product # PA5-13105) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = he... View More
Product Details
PA5-13105
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1038-1067 amino acids from the C-terminal region of human ABCB11
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABC member 16, MDR/TAP subfamily; ABC transporter; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, sub-family B, member 11; Bile salt export pump; progressive familial intrahepatic cholestasis 2; Sister of P-glycoprotein; sister p-glycoprotein; unnamed protein product
Gene Aliases: ABC16; ABCB11; BRIC2; BSEP; Lith1; PFIC-2; PFIC2; PGY4; SPGP
UniProt ID: (Human) O95342, (Mouse) Q9QY30
Entrez Gene ID: (Human) 8647, (Mouse) 27413
nucleotide binding
protein binding
ATP binding
xenobiotic-transporting ATPase activity
bile acid transmembrane transporter activity
canalicular bile acid transmembrane transporter activity
bile acid-exporting ATPase activity
ATPase activity
ABC-type transporter activity
drug transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
ATP-binding cassette (ABC) transporter
fatty acid metabolic process
bile acid biosynthetic process
xenobiotic metabolic process
drug transmembrane transport
lipid transport
bile acid metabolic process
bile acid and bile salt transport
canalicular bile acid transport
protein ubiquitination
regulation of fatty acid beta-oxidation
cholesterol homeostasis
drug export
transmembrane transport
lipid homeostasis
phospholipid homeostasis
positive regulation of bile acid secretion
regulation of bile acid metabolic process
transport
response to drug
anion transmembrane transport
organic acid transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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