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Invitrogen
beta-2 Adrenergic Receptor Polyclonal Antibody
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FIGURE: 1 / 3
beta-2 Adrenergic Receptor Antibody (PA5-14117) in IHC (P)
Immunohistochemistry analysis of beta-2 Adrenergic Receptor in formalin-fixed and paraffin-embedded human hepatocarcinoma tissue. Samples were incubated with beta-2 Adrenergic Receptor polyclonal antibody (Product # PA5-14117) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has n... View More
Product Details
PA5-14117
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 236-264 amino acids from human ADRB2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; AR beta2; beta 2-AR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286; putative; unnamed protein product
Gene Aliases: Adrb-2; ADRB2; ADRB2R; ADRBR; ARB2; B2AR; Badm; BAR; BETA2AR; Gpcr7
UniProt ID: (Human) P07550, (Mouse) P18762
Entrez Gene ID: (Human) 154, (Mouse) 11555
beta-amyloid binding
G-protein coupled receptor activity
adrenergic receptor activity
beta-adrenergic receptor activity
beta2-adrenergic receptor activity
protein binding
adenylate cyclase binding
potassium channel regulator activity
enzyme binding
identical protein binding
protein homodimerization activity
macromolecular complex binding
norepinephrine binding
G-protein alpha-subunit binding
signal transducer activity
drug binding
B2 bradykinin receptor binding
protein complex binding
dopamine binding
ionotropic glutamate receptor binding
epinephrine binding
G-protein coupled receptor
regulation of systemic arterial blood pressure by norepinephrine-epinephrine
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
regulation of sodium ion transport
transcription from RNA polymerase II promoter
receptor-mediated endocytosis
smooth muscle contraction
regulation of smooth muscle contraction
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
endosome to lysosome transport
response to cold
positive regulation of bone mineralization
heat generation
negative regulation of multicellular organism growth
positive regulation of MAPK cascade
bone resorption
negative regulation of G-protein coupled receptor protein signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of smooth muscle contraction
brown fat cell differentiation
positive regulation of mini excitatory postsynaptic potential
adrenergic receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
regulation of blood vessel diameter
AMPA selective glutamate receptor signaling pathway
positive regulation of cold-induced thermogenesis
positive regulation of cAMP/PKA signal transduction
positive regulation of autophagosome maturation
positive regulation of lipophagy
cellular response to beta-amyloid
response to psychosocial stress
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
diaphragm contraction
positive regulation of the force of heart contraction by epinephrine
activation of adenylate cyclase activity
cell-cell signaling
positive regulation of cell proliferation
associative learning
positive regulation of sodium ion transport
negative regulation of angiogenesis
negative regulation of ossification
positive regulation of protein ubiquitination
positive regulation of ATPase activity
synaptic transmission, glutamatergic
negative regulation of urine volume
wound healing
regulation of vasodilation
positive regulation of apoptotic process
positive regulation of potassium ion transport
positive regulation of heart contraction
positive regulation of vasodilation
positive regulation of skeletal muscle tissue growth
negative regulation of inflammatory response
regulation of calcium ion transport
regulation of sensory perception of pain
excitatory postsynaptic potential
cellular response to hypoxia
negative regulation of platelet aggregation
mitophagy in response to mitochondrial depolarization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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