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Invitrogen
ALPL Polyclonal Antibody
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Product Details
PA5-143291
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-ELQKLNTNVAKN (aa 42-53).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to recognize isoform 1 (NP_000469.3) only. The immunizing peptide represents the N terminus of the mature protein.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
Alkaline phosphatase is a homodimeric protein enzyme (86 kDa), containing two zinc atoms crucial to its catalytic function per monomer, and it is optimally active at alkaline pH environments. The enzyme is found in prokaryotes and eukaryotes, with the same general function but in different structural forms suitable to organism's environment. ALP plays a role in liver metabolism and development within the skeleton. In bacteria, ALP acts as a source of inorganic phosphate. In yeast, ALP can be a useful protein for studying membrane protein sorting.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; FLJ40094; FLJ93059; glycerophosphatase; liver/bone/kidney-type alkaline phosphatase; MGC161443; MGC167935; Phosphoamidase; Phosphocreatine phosphatase; tissue non-specific alkaline phosphatase; tissue-nonspecific ALP; unnamed protein product
Gene Aliases: ALPL; AP-TNAP; APTNAP; HOPS; HPPA; HPPC; HPPI; HPPO; TNALP; TNAP; TNS-ALP; TNSALP
UniProt ID: (Human) P05186
Entrez Gene ID: (Human) 249
alkaline phosphatase activity
inorganic diphosphatase activity
calcium ion binding
pyrophosphatase activity
hydrolase activity
phosphatase activity
ATPase activity
pyridoxal phosphatase activity
adenosine-diphosphatase activity
metal ion binding
phosphoamidase activity
phosphoethanolamine phosphatase activity
skeletal system development
osteoblast differentiation
endochondral ossification
developmental process involved in reproduction
cellular homeostasis
bone mineralization
biomineral tissue development
response to lipopolysaccharide
response to insulin
response to vitamin D
response to vitamin B6
response to macrophage colony-stimulating factor
pyridoxal phosphate metabolic process
response to antibiotic
response to glucocorticoid
phosphate ion homeostasis
calcium ion homeostasis
cementum mineralization
positive regulation of cold-induced thermogenesis
futile creatine cycle
inhibition of non-skeletal tissue mineralization
response to sodium phosphate
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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