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Invitrogen
SKP1 Polyclonal Antibody
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Product Details
PA5-17468
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues of human Skp1
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteasome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; Cyclin-A/CDK2-associated protein p19; MGC34403; OCP-2; OCP-II; OCP-II protein; Organ of Corti protein 2; Organ of Corti protein II; p19A; p19skp1; polypeptide 1-like; RNA polymerase II elongation factor-like protein; RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1; S-phase kinase-associated protein 1A; SIII; Transcription elongation factor B polypeptide 1-like
Gene Aliases: 15kDa; 2610043E24Rik; 2610206H23Rik; EMC19; OCP-II; OCP2; p19A; p19Skp1; SKP1; SKP1A; TCEB1L
UniProt ID: (Human) P63208, (Rat) Q6PEC4, (Mouse) Q9WTX5
Entrez Gene ID: (Human) 6500, (Rat) 287280, (Mouse) 21402
protein binding
beta-catenin binding
protein domain specific binding
cullin family protein binding
molecular function activator activity
ubiquitin ligase complex scaffold activity
F-box domain binding
protein binding, bridging involved in substrate recognition for ubiquitination
ubiquitin ligase activator activity
ubiquitin-protein transferase activity
ubiquitin-protein ligase
protein polyubiquitination
chromatin remodeling
ubiquitin-dependent protein catabolic process
protein monoubiquitination
apoptotic process
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
maintenance of protein location in nucleus
axon development
protein K48-linked ubiquitination
positive regulation of epithelial cell apoptotic process
histone H2A monoubiquitination
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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