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Invitrogen
Catalase Polyclonal Antibody
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FIGURE: 1 / 6
Catalase Antibody (PA5-18531) in IHC (P)
Immunohistochemistry analysis of Catalase in human spleen. Samples were incubated with Catalase polyclonal antibody (Product # PA5-18531) using a dilution of 2 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18531
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (DKYNAEKPKNAIHT) corresponding to the internal amino acids of CAT (aa 498-511).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
Catalase is a homotetrameric heme-containing enzyme present within the matrix of all peroxisomes. It carries out a dismutation reaction in which hydrogen peroxide is converted to water and oxygen. Human catalase has the last four amino acids (-KANL) at the extreme C-terminus for peroxisome targeting. The monomer of human catalase is 61.3 kDa in molecular size. Catalase has been implicated as an important factor in inflammation, mutagenesis, prevention of apoptosis, and stimulation of a wide spectrum of tumors. Loss of catalase leads to the human genetic disease, acatalasemia, or Takahara's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CAT; Catalase; catalase 1; CTA1; epididymis secretory sperm binding protein; HGNC:1516; MGC138422; MGC138424; unnamed protein product
Gene Aliases: 2210418N07; Cas-1; Cas1; CAT; Cs-1
UniProt ID: (Human) P04040, (Mouse) P24270
Entrez Gene ID: (Human) 847, (Mouse) 12359
aminoacylase activity
catalase activity
peroxidase activity
antioxidant activity
oxidoreductase activity
oxidoreductase activity, acting on peroxide as acceptor
enzyme binding
heme binding
identical protein binding
protein homodimerization activity
metal ion binding
NADP binding
receptor binding
peroxidase
response to reactive oxygen species
osteoblast differentiation
ureteric bud development
response to hypoxia
kidney development
triglyceride metabolic process
response to oxidative stress
cholesterol metabolic process
aerobic respiration
response to xenobiotic stimulus
response to UV
response to toxic substance
response to light intensity
UV protection
response to ozone
response to lead ion
response to activity
response to inactivity
hemoglobin metabolic process
response to estradiol
response to insulin
response to vitamin A
response to vitamin E
response to L-ascorbic acid
response to hydrogen peroxide
hydrogen peroxide catabolic process
negative regulation of apoptotic process
response to ethanol
response to cadmium ion
positive regulation of cell division
positive regulation of protein kinase B signaling
response to hyperoxia
cellular detoxification of hydrogen peroxide
response to fatty acid
cellular response to growth factor stimulus
response to amitrole
response to phenylpropanoid
positive regulation of phosphatidylinositol 3-kinase signaling
negative regulation of NF-kappaB transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein tetramerization
protein homotetramerization
oxidation-reduction process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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