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Invitrogen
Caspase 12 Polyclonal Antibody
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Product Details
PA5-20033
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to 16 amino acids within the large cleavage product of murine caspase-12. The immunogen is located within amino acids 170 - 220 of Caspase-12.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive controls are human heart, mouse heart, or rat heart tissue lysates.
PA5-20033 can be used with blocking peptide PEP-0152.
Caspase-12 antibody is predicted to have no cross reactivity to other members in the caspase family.
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CASP-12; caspase 12 pseudogene 1; Caspase-12; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415
Gene Aliases: CASP-12; CASP12; CASP12P1; UNQ9415/PRO34398
UniProt ID: (Human) Q6UXS9, (Rat) Q920D5, (Mouse) O08736
Entrez Gene ID: (Human) 100506742, (Rat) 156117, (Mouse) 12364
proteolysis
apoptotic process
regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of inflammatory response
aging
response to cold
response to inorganic substance
response to iron(III) ion
response to organonitrogen compound
protein autoprocessing
endoplasmic reticulum unfolded protein response
response to anoxia
response to endoplasmic reticulum stress
response to nicotine
response to drug
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to ethanol
regulation of inflammatory response
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
execution phase of apoptosis
intrinsic apoptotic signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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