A suggested positive control is human liver tissue lysate.
PA5-20339 can be used with blocking peptide PEP-0459.
Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.
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Protein Aliases: Protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2
Gene Aliases: CEMCOX1; MYP6; SCO1L; SCO2
UniProt ID: (Human) O43819
Entrez Gene ID: (Human) 9997