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Invitrogen

IRGM Polyclonal Antibody

View all (5) IRGM antibodies

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Product Details

PA5-20508

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (IHC)

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 14 amino acid peptide near the center of the human IRGM.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11156787

Product Specific Information

A suggested positive control is human brain tissue lysate.

PA5-20508 can be used with blocking peptide PEP-0628.

Target Information

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. In mouse, IRGM belongs to a family of -gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: immunity related GTPase m1; Immunity-related GTPase family M protein; Immunity-related GTPase family M protein 1; immunity-related GTPase family, M; immunity-related GTPase family, M1; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; Interferon-inducible GTPase 3; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG 47; LRG-47; LRG-47-like protein; MGC149263

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Gene Aliases: IBD19; Ifggd3; IFI1; Iigp3; Iipg3; IRGM; IRGM1; LRG-47; LRG47

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UniProt ID: (Human) A1A4Y4, (Rat) Q6AYC2, (Mouse) Q60766

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Entrez Gene ID: (Human) 345611, (Rat) 303090, (Mouse) 15944

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Function(s)
nucleotide binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding hydrolase activity protein kinase binding protein binding, bridging protein serine/threonine kinase activator activity CARD domain binding BH3 domain binding cardiolipin binding
Process(es)
immune system process autophagy defense response innate immune response autophagosome assembly positive regulation of protein phosphorylation inflammatory response lysosome organization positive regulation of autophagy positive regulation of peptidyl-threonine phosphorylation protein catabolic process protein destabilization negative regulation of type I interferon production negative regulation of interferon-gamma production positive regulation of peptidyl-serine phosphorylation cellular response to interferon-beta defense response to bacterium positive regulation of macrophage activation negative regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly NLRP3 inflammasome complex assembly negative regulation of innate immune response negative regulation of defense response to virus negative regulation of inflammatory response protein stabilization defense response to Gram-negative bacterium positive regulation of interferon-gamma-mediated signaling pathway regulation of protein complex stability protein lipidation involved in autophagosome assembly CAMKK-AMPK signaling cascade protein-containing complex assembly nucleotide-binding oligomerization domain containing 2 signaling pathway protein targeting to vacuole involved in autophagy cellular response to lipopolysaccharide positive regulation of protein serine/threonine kinase activity positive regulation of mitochondrial fission autophagosome maturation cellular response to virus antibacterial innate immune response negative regulation of cGAS/STING signaling pathway negative regulation of protein localization to nucleus positive regulation of protein localization to nucleus negative regulation of NLRP3 inflammasome complex assembly positive regulation of autophagosome maturation positive regulation of mitophagy positive regulation of xenophagy positive regulation of lysosome organization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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