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Invitrogen
CYP1B1 Polyclonal Antibody
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Product Details
PA5-23139
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 400-450 of human CYP1B1.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aryl hydrocarbon hydroxylase; CYPIB1; Cytochrome P450 1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); dioxin-inducible cytochrome p450; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; unnamed protein product; xenobiotic monooxygenase
Gene Aliases: ASGD6; CP1B; CYP1B1; CYPIB1; GLC3A; P4501B1
UniProt ID: (Human) Q16678
Entrez Gene ID: (Human) 1545
monooxygenase activity
iron ion binding
protein binding
steroid hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
lyase activity
heme binding
metal ion binding
testosterone 6-beta-hydroxylase activity
estrogen 16-alpha-hydroxylase activity
estrogen 2-hydroxylase activity
hydroperoxy icosatetraenoate dehydratase activity
angiogenesis
trabecular meshwork development
lipid metabolic process
fatty acid metabolic process
steroid catabolic process
xenobiotic metabolic process
nitric oxide biosynthetic process
cell adhesion
steroid metabolic process
estrogen metabolic process
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to oxidative stress
toxin metabolic process
response to toxic substance
positive regulation of vascular endothelial growth factor production
sterol metabolic process
arachidonic acid metabolic process
epoxygenase P450 pathway
collagen fibril organization
negative regulation of cell migration
negative regulation of NF-kappaB transcription factor activity
negative regulation of cell adhesion mediated by integrin
xenobiotic catabolic process
hormone metabolic process
benzene-containing compound metabolic process
retinol metabolic process
retinal metabolic process
positive regulation of apoptotic process
blood vessel endothelial cell migration
endothelial cell migration
positive regulation of angiogenesis
positive regulation of JAK-STAT cascade
membrane lipid catabolic process
blood vessel morphogenesis
retina vasculature development in camera-type eye
retinal blood vessel morphogenesis
cellular response to hydrogen peroxide
endothelial cell-cell adhesion
omega-hydroxylase P450 pathway
olefinic compound metabolic process
regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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