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Invitrogen

beta-Arrestin 2 Polyclonal Antibody

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beta-Arrestin 2 Polyclonal Antibody

Product Details

PA5-23296

Applications
Tested Dilution
Publications

Western Blot (WB)

0.25-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Horse, Human, Mouse, Non-human primate, Rat, Xenopus, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A peptide sequence corresponding to an area between amino acids 1 and 50 of human ARRB2.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2540820

Product Specific Information

Sequence homology: Chimpanzee/platypus/opssoum/boar (100%), Tetradon (94%).

Target Information

Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activated GPCR interaction protein; ARRB2; arrestin 3; Arrestin beta-2; arrestin-3; beta arr2; beta-arrestin 2 long isoform; beta-arrestin 2 short isoform; Beta-arrestin-2; Non-visual arrestin-3; unnamed protein product

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Gene Aliases: AI326910; ARB2; ARR2; ARRB2; AW122872; BARR2; BARRES

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UniProt ID: (Human) P32121, (Mouse) Q91YI4, (Rat) P29067

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Entrez Gene ID: (Bovine) 281638, (Horse) 100072892, (Dog) 607262, (Human) 409, (Mouse) 216869, (Rat) 25388

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Function(s)
inositol hexakisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol binding G-protein coupled receptor binding receptor binding protein binding enzyme binding protein binding, bridging ubiquitin protein ligase binding angiotensin receptor binding D1 dopamine receptor binding protein kinase B binding binding, bridging protein domain specific binding alpha-1A adrenergic receptor binding alpha-1B adrenergic receptor binding type 1 angiotensin receptor binding follicle-stimulating hormone receptor binding type 2A serotonin receptor binding platelet activating factor receptor binding protein complex binding protein complex scaffold mitogen-activated protein kinase binding 14-3-3 protein binding clathrin binding scaffold/adaptor protein
Process(es)
desensitization of G-protein coupled receptor protein signaling pathway G-protein coupled receptor internalization positive regulation of receptor internalization signal transduction protein transport receptor internalization transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway I-kappaB kinase/NF-kappaB signaling adult walking behavior regulation of G-protein coupled receptor protein signaling pathway negative regulation of signal transduction positive regulation of cardiac muscle hypertrophy positive regulation of gene expression protein ubiquitination sensory perception of pain negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity positive regulation of synaptic transmission, dopaminergic negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of natural killer cell mediated cytotoxicity modulation of synaptic transmission positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling excitatory postsynaptic potential cell chemotaxis positive regulation of ERK1 and ERK2 cascade postsynaptic signal transduction beta-arrestin-dependent dopamine receptor signaling pathway positive regulation of intracellular signal transduction positive regulation of cardiac muscle cell differentiation regulation of protein phosphorylation positive regulation of protein phosphorylation desensitization of G-protein coupled receptor protein signaling pathway by arrestin transport endocytosis G-protein coupled receptor signaling pathway positive regulation of protein ubiquitination positive regulation of peptidyl-serine phosphorylation negative regulation of GTPase activity negative regulation of smooth muscle cell apoptotic process follicle-stimulating hormone signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of peptidyl-tyrosine phosphorylation detection of temperature stimulus involved in sensory perception of pain positive regulation of calcium ion transport regulation of androgen receptor signaling pathway negative regulation of release of cytochrome c from mitochondria positive regulation of DNA biosynthetic process brain development regulation of cAMP biosynthetic process regulation of cAMP catabolic process
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