Search
Invitrogen
CD44 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
CD44 Antibody (PA5-29590) in IHC (P)
CD44 Polyclonal Antibody detects CD44 protein at cell membrane on human ovarian carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human ovarian carcinoma. CD44 Polyclonal Antibody (Product # PA5-29590) diluted at 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-29590
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human CD44. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Amount
65 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLa.
Predicted reactivity: Mouse (87%), Rat (88%), Dog (93%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CD44; CD44 antigen; CD44 molecule; CD44 molecule (Indian blood group); CD44R1; CDw44; CDw44 antigen precursor; cell surface glycoprotein CD44; Cell surface glycoprotein CD44 (hyaluronate binding protein); cell-cell and cell-matrix adhesion interaction glycoprotein isoform; cell-surface glycoprotein; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; Hermes antigen gp90 homing receptor precursor; homing cell adhesion molecule; homing function and Indian blood group system; homing receptor; HUTCH-I; hyaluronan receptor; hyaluronan-binding protein; Hyaluronate receptor; In(Lu) related-p80; Indian blood group antigen; PGP I; PGP-1; PGP-I; PGPI; phagocyte glycoprotein 1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44; unnamed protein product
Gene Aliases: CD44; CD44A; CDW44; CSPG8; ECM-III; ECMR-III; H-CAM; HCELL; Hermes-1; HUTCH-1; HUTCH-I; LHR; MC56; MDU2; MDU3; METAA; MIC4; Pgp1; RHAMM
UniProt ID: (Human) P16070, (Rat) P26051
Entrez Gene ID: (Human) 960, (Rat) 25406
inflammatory response
cell adhesion
cell-matrix adhesion
anatomical structure morphogenesis
cell migration
cytokine-mediated signaling pathway
hyaluronan catabolic process
positive regulation of heterotypic cell-cell adhesion
T cell activation
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
wound healing, spreading of cells
cellular response to fibroblast growth factor stimulus
system development
cartilage development
positive regulation of ERK1 and ERK2 cascade
monocyte aggregation
cell-cell adhesion
positive regulation of monocyte aggregation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of lamellipodium morphogenesis
regulation of cell growth
branching involved in ureteric bud morphogenesis
blood vessel maturation
wound healing involved in inflammatory response
negative regulation of mature B cell apoptotic process
positive regulation of gene expression
response to organic cyclic compound
Wnt signaling pathway
neuron projection development
positive regulation of neutrophil apoptotic process
positive regulation of peptidyl-serine phosphorylation
response to vitamin A
macrophage fusion
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of peptidyl-tyrosine phosphorylation
branching involved in prostate gland morphogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support