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Invitrogen
USP47 Polyclonal Antibody
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FIGURE: 1 / 3
USP47 Antibody (PA5-30661) in IHC (P)
USP47 Polyclonal Antibody detects USP47 protein at cytoplasm on human ovarian carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded ovarian carcinoma. USP47 Polyclonal Antibody (Product # PA5-30661) dilution: 1:250. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-30661
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human USP47. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.54 mg/mL
Amount
54 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: U87-MG, mouse brain.
Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (85%), Xenopus laevis (86%), Chicken (94%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 47; Trf (TATA binding protein-related factor)-proximal homolog; Ubiquitin carboxyl-terminal hydrolase 47; ubiquitin specific protease 47; Ubiquitin thioesterase 47; ubiquitin thiolesterase 47; Ubiquitin-specific-processing protease 47; unnamed protein product
Gene Aliases: 4930502N04Rik; A630020C16Rik; TRFP; USP47
UniProt ID: (Human) Q96K76, (Mouse) Q8BY87
Entrez Gene ID: (Human) 55031, (Mouse) 74996
DNA repair
base-excision repair
proteolysis
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
protein deubiquitination
regulation of protein stability
monoubiquitinated protein deubiquitination
positive regulation of canonical Wnt signaling pathway
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
ubiquitin-dependent protein catabolic process
negative regulation of G2/M transition of mitotic cell cycle
positive regulation of cell growth
cellular response to UV
response to drug
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
regulation of proteasomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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