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Invitrogen
GPR68 Polyclonal Antibody
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Product Details
PA5-33756
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human GPR68.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bovine, Hamster, Panda, Horse, Rabbit, Pig (100%).
Target Information
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brgr1; Brgrb; G protein-coupled receptor 68; G protein-coupled receptor RGR1; G-protein coupled receptor 12A; G-protein coupled receptor 68; GPR12A; OGR-1; OGR1; GPR68; ovarian cancer G protein-coupled receptor, 1; Ovarian cancer G-protein coupled receptor 1; Ovarian cancer G-protein coupled receptor 1 homolog; sphingosylphosphorylcholine receptor
Gene Aliases: AI2A6; BB131428; GPR12A; GPR68; OGR1
UniProt ID: (Bovine) O46685, (Human) Q15743, (Mouse) Q8BFQ3
G-protein coupled receptor signaling pathway
positive regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of monocyte differentiation
positive regulation of osteoclast development
inflammatory response
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
insulin secretion
monocyte differentiation
positive regulation of insulin secretion
response to fluid shear stress
osteoclast development
cellular response to pH
cellular response to acidic pH
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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