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Invitrogen
VKORC1 Polyclonal Antibody
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Product Details
PA5-34358
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid synthetic peptide near the amino terminus of human VKORC1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is A549 cell lysate.
PA5-34358 can be used with blocking peptide PEP-1401.
Target Information
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMAGE3455200; phylloquinone epoxide reductase; transmembrane protein; TMP576; unnamed protein product; vitamin K dependent clotting factors deficiency 2; Vitamin K epoxide reductase complex subunit 1; Vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive)
Gene Aliases: D7Wsu86e; EDTP308; MST134; MST576; MSTP134; MSTP576; UNQ308/PRO351; VKCFD2; VKOR; VKORC1
UniProt ID: (Human) Q9BQB6, (Mouse) Q9CRC0
Entrez Gene ID: (Human) 79001, (Mouse) 27973
xenobiotic metabolic process
blood coagulation
peptidyl-glutamic acid carboxylation
vitamin K metabolic process
positive regulation of coagulation
bone development
response to organonitrogen compound
response to organic cyclic compound
drug metabolic process
regulation of blood coagulation
vitamin K biosynthetic process
response to antibiotic
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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