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Invitrogen
PTGER4 Polyclonal Antibody
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FIGURE: 1 / 2
PTGER4 Antibody (PA5-35259) in IHC (P)
Immunohistochemistry analysis of PTGER4 in paraffin-embedded human brain section. Samples were incubated with PTGER4 polyclonal antibody (Product # PA5-35259) using a dilution of 1:25 followed by an undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
Product Details
PA5-35259
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 242-269 amino acids from the central region of human PTGER4
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
120 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, rat and rabbit based on sequence homology.
Target Information
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EP1; G-protein coupled receptor; PTGER4; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor
Gene Aliases: EP4; EP4R; PTGER2; PTGER4; Ptgerep4
UniProt ID: (Human) P35408, (Mouse) P32240
Entrez Gene ID: (Human) 5734, (Mouse) 19219
MAPK cascade
negative regulation of cytokine production
positive regulation of cytokine production
inflammatory response
immune response
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
JNK cascade
response to mechanical stimulus
negative regulation of integrin activation
response to lipid
response to prostaglandin E
T-helper cell differentiation
negative regulation of inflammatory response
positive regulation of inflammatory response
regulation of stress fiber assembly
bone development
ERK1 and ERK2 cascade
cellular response to mechanical stimulus
cellular response to prostaglandin E stimulus
negative regulation of eosinophil extravasation
intestine smooth muscle contraction
positive regulation of smooth muscle cell migration
regulation of ossification
positive regulation of cAMP biosynthetic process
response to lipopolysaccharide
positive regulation of interleukin-8 production
positive regulation of urine volume
positive regulation of renal sodium excretion
positive regulation of bone resorption
negative regulation of cytokine secretion
positive regulation of cytokine secretion
negative regulation of oxidoreductase activity
positive regulation of mucus secretion
ductus arteriosus closure
positive regulation of hyaluronan biosynthetic process
positive regulation of ovarian follicle development
positive regulation of antral ovarian follicle growth
positive regulation of neutrophil extravasation
negative regulation of peroxidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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