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Invitrogen

Phospho-IKK beta (Tyr188) Polyclonal Antibody

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Phospho-IKK beta (Tyr188) Polyclonal Antibody

Product Details

PA5-36653

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Tyrosine 188
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2553638

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 86 kDa.

Purity is >95% by SDS-PAGE.

Target Information

Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex. Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-2; IKK-B; IKK-beta; IKK2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; nuclear factor kappa B kinase subunit beta; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB; unnamed protein product

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Gene Aliases: AI132552; AIM-1; IKBKB; IKK-2; IKK-beta; IKK2; IKK[b]; IKKB; IKKbeta; IMD15; IMD15A; IMD15B; NFKBIKB

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UniProt ID: (Human) O14920, (Mouse) O88351, (Rat) Q9QY78

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Entrez Gene ID: (Human) 3551, (Mouse) 16150, (Rat) 84351

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding IkappaB kinase activity kinase activity transferase activity protein kinase binding identical protein binding protein homodimerization activity protein heterodimerization activity scaffold protein binding protein serine kinase activity transferrin receptor binding receptor signaling protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase protein modifying enzyme
Process(es)
protein polyubiquitination pattern recognition receptor signaling pathway stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent MyD88-dependent toll-like receptor signaling pathway regulation of transcription from RNA polymerase II promoter protein phosphorylation inflammatory response I-kappaB kinase/NF-kappaB signaling response to virus positive regulation of macromolecule metabolic process regulation of tumor necrosis factor-mediated signaling pathway peptidyl-serine phosphorylation signal transduction involved in regulation of gene expression tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway toll-like receptor 3 signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade protein maturation interleukin-1-mediated signaling pathway cellular response to tumor necrosis factor protein localization to plasma membrane negative regulation of cytokine production involved in inflammatory response regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly B cell homeostasis I-kappaB phosphorylation positive regulation of cell proliferation positive regulation of sodium ion transport phosphorylation signal transduction by protein phosphorylation neuron projection development serine phosphorylation of STAT protein positive regulation of neuron death positive regulation of cation channel activity skeletal muscle contraction response to toxic substance response to drug response to fatty acid
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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