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Invitrogen

Phospho-NFkB p105 (Ser932) Polyclonal Antibody

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Phospho-NFkB p105 (Ser932) Polyclonal Antibody

Product Details

PA5-37662

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of serine 932 (E-T-S(p)-F-R) derived from Human NF-kappa-B-p105.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554270

Product Specific Information

A suggested positive control for Western blot is 293 cells; suggested positive control for IHC is human breast carcinoma.

Target Information

NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA-binding factor KBF1; EBP-1; NF kappaB1; NF KB; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappaB p50; NF-kB p105; nuclear factor; nuclear factor kappa b; nuclear factor kappa-B DNA binding subunit; nuclear factor kappaB p50; Nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; nuclear factor-kappaB p50; p50 subunit of NF kappaB; p50 subunit of NF-kappaB; unnamed protein product

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Gene Aliases: CVID12; EBP-1; KBF1; NF-kappa-B1; NF-kappaB; NF-kappaB1; NF-kappabeta; NF-kB; NF-KB1; NFkappaB; NFKB-p105; NFKB-p50; NFKB1; p105; p50; p50/p105

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UniProt ID: (Human) P19838, (Mouse) P25799, (Rat) Q63369

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Entrez Gene ID: (Human) 4790, (Mouse) 18033, (Rat) 81736

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity protein binding identical protein binding actinin binding sequence-specific DNA binding protein sequestering activity regulatory region DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding double-stranded DNA binding heat shock protein binding protein homodimerization activity transcription regulatory region DNA binding protein heterodimerization activity transcription factor binding Rel homology transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade negative regulation of cytokine production immune system process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter apoptotic process inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling JNK cascade gene expression regulation of gene expression positive regulation of macromolecule biosynthetic process negative regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol efflux positive regulation of lipid storage negative regulation of vitamin D biosynthetic process signal transduction involved in regulation of gene expression negative regulation of interleukin-12 production tumor necrosis factor-mediated signaling pathway response to muscle stretch NIK/NF-kappaB signaling negative regulation of apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response positive regulation of inflammatory response B cell receptor signaling pathway mammary gland involution positive regulation of transcription initiation from RNA polymerase II promoter cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to nicotine cellular response to cytokine stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to dsRNA positive regulation of canonical Wnt signaling pathway cellular response to interleukin-17 cellular response to virus antibacterial innate immune response negative regulation of cytokine production involved in inflammatory response positive regulation of hyaluronan biosynthetic process cellular response to angiotensin positive regulation of miRNA metabolic process transcription, DNA-templated response to oxidative stress negative regulation of calcidiol 1-monooxygenase activity response to cytokine negative regulation of interleukin-12 biosynthetic process innate immune response lymph node development cellular response to peptide hormone stimulus response to bacterium response to copper ion cellular response to interleukin-1
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