A recommended positive control is SK-N-SH cell lysate.
At least two isoforms are known to exist; this antibody will recognize both isoforms. POU2F3 antibody is not expected to cross-react with other members of the POU domain class 2 family.
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
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Protein Aliases: 11-Oct; FLJ40063; MGC126698; Oct-11; Octamer-binding protein 11; Octamer-binding transcription factor 11; OTF-11; POU domain transcription factor OCT11a; POU domain, class 2, transcription factor 3; Rov 1 pou-homeodomain protein; Transcription factor PLA-1; Transcription factor Skn-1
Gene Aliases: Epoc-1; OCT-11; Oct-11a; OCT11; OTF-11; OTF11; PLA-1; PLA1; POU2F3; Skin; Skin-1a; Skn-1a; Skn-li
UniProt ID: (Human) Q9UKI9