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Invitrogen
GPNMB Polyclonal Antibody
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FIGURE: 1 / 3
GPNMB Antibody (PA5-46926) in IHC (P)
Immunohistochemical analysis of GPNMB in immersion fixed paraffin-embedded sections of human liver. Samples were incubated in GPNMB polyclonal antibody (Product # PA5-46926) using a dilution of 3 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to Kupffer cells.
Product Details
PA5-46926
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Osteoactivinisoform b Lys23-Asn486
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In sandwich ELISAs, less than 2% cross-reactivity with recombinant mouse Osteoactivin is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glycoprotein (transmembrane) nmb; glycoprotein nmb-like protein; glycoprotein nonmetastatic melanoma protein B; Hematopoietic growth factor inducible neurokinin-1 type; hematopoietic growth factor-inducible neurokinin-1 protein; NMB; osteoactivin; transmembrane glycoprotein HGFIN; Transmembrane glycoprotein NMB; unnamed protein product
Gene Aliases: GPNMB; HGFIN; NMB; PLCA3; UNQ1725/PRO9925
UniProt ID: (Human) A4D155
Entrez Gene ID: (Human) 10457
negative regulation of cytokine production
cell adhesion
signal transduction
cell-cell signaling
negative regulation of cell proliferation
positive regulation of cell migration
negative regulation of tumor necrosis factor production
regulation of tissue remodeling
negative regulation of T cell proliferation
regulation of angiogenesis
negative regulation of T cell activation
positive chemotaxis
positive regulation of ERK1 and ERK2 cascade
negative regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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