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Invitrogen
Layilin Polyclonal Antibody
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Product Details
PA5-47357
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Layilin Ala22-Glu220
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs and Western blots, approximately 15% cross-reactivity with recombinant mouse Layilin is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Layilin is a cell surface receptor encoded by the LAYN gene, known for its involvement in cell adhesion and motility processes. It is a member of the C-type lectin-like domain protein family and plays a crucial role in mediating interactions with the extracellular matrix. Layilin is associated with cytoskeletal reorganization, impacting cellular processes such as shape change, migration, and stabilization of cell-matrix contacts. It has been shown to interact with other proteins like talin, contributing to the linkage between the cell membrane and the actin cytoskeleton, which is vital for maintaining cell structure and facilitating movement. Layilin's role in cell adhesion and motility makes it significant in developmental processes and wound healing. Additionally, dysregulation of layilin expression has been implicated in cancer metastasis, where altered adhesive properties and increased motility contribute to tumor progression and dissemination. Research is ongoing to explore the detailed mechanisms of layilin's function and its potential as a target for therapeutic intervention in diseases characterized by abnormal cell migration and adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ30977; FLJ31092; Layilin; LYAN; unnamed protein product
Gene Aliases: LAYN; UNQ208/PRO234
UniProt ID: (Human) Q6UX15
Entrez Gene ID: (Human) 143903
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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