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Invitrogen
DMP1 Polyclonal Antibody
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FIGURE: 1 / 1
DMP1 Antibody (PA5-47621) in IHC (F)
Immunohistochemical analysis of DMP1 in immersion fixed frozen sections of embryonic mouse rib (E15.5). Samples were incubated in DMP1 polyclonal antibody (Product # PA5-47621) using a dilution of 10 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red) and counterstained with DAPI (blue).
Product Details
PA5-47621
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse DMP-1 Leu17-Tyr503
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant human DMP-1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AG1; Dentin matrix acidic phosphoprotein 1; DMP 1; DMP-1; MGC130441; serine rich acidic phosphoprotein
Gene Aliases: AV020965; Dmp; Dmp1; PP
UniProt ID: (Mouse) O55188
Entrez Gene ID: (Mouse) 13406
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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