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Invitrogen
ING1 Polyclonal Antibody
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FIGURE: 1 / 4
ING1 Antibody (PA5-47772) in ICC/IF
Immunocytochemistry analysis of ING1 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line. The cells were labeled with ING1 Goat Polyclonal Antibody (Product # PA5-47772) using a dilution of 10 µg/mL for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel) counterstained with DAPI (blue, lower panel).
Product Details
PA5-47772
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human ING1 Met213-Ser327
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) ING2 and less than 1% cross-reactivity with with rhING3, rhING4, and rhING5 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: growth inhibitor ING1; growth inhibitor; tumor suppressor candidate; growth inhibitory protein ING1; Inhibitor of growth protein 1; p33ING; p33ING1; tumor suppressor ING1; unnamed protein product
Gene Aliases: ING1; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a
UniProt ID: (Human) Q9UK53
Entrez Gene ID: (Human) 3621
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
protein import into nucleus
negative regulation of cell proliferation
negative regulation of cell growth
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of programmed cell death
positive regulation of transcription, DNA-templated
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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