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Invitrogen
SEMA4C Polyclonal Antibody
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FIGURE: 1 / 3
SEMA4C Antibody (PA5-47814) in IHC (P)
Immunohistochemical analysis of SEMA4C in immersion fixed paraffin-embedded sections of human brain (cortex). Samples were incubated in SEMA4C polyclonal antibody (Product # PA5-47814) using a dilution of 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic . Tissue was stained using the Anti-She... View More
Product Details
PA5-47814
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Semaphorin 4C Ala21-Gly663
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse (rm) Sema4C is observed, and approximately 10% cross-reactivity with recombinant human (rh) Sema4G is observed, and less than 5% cross-reactivity with rhSema3B and rmSema3F is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
SEMA4C (semaphorin-4C), also known as SEMAF, is an 833 amino acid single-pass type I membrane protein that contains one sema domain, one PSI domain and one Ig-like C2-type domain. Expressed in a variety of tissues, including lung, kidney and brain, SEMA4C interacts with GIPC and NCDN and is thought to play a role in the formation of neural networks during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ20369; M-Sema F; MGC126382; MGC126383; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C; Semaphorin-4C; unnamed protein product
Gene Aliases: KIAA1739; M-SEMA-F; SEMA4C; SEMACL1; SEMAF; SEMAI; UNQ5855/PRO34487
UniProt ID: (Human) Q9C0C4
Entrez Gene ID: (Human) 54910
neural crest cell migration
neural tube closure
nervous system development
axon guidance
cell migration in hindbrain
cerebellum development
cell differentiation
positive regulation of cell migration
positive regulation of stress-activated MAPK cascade
muscle cell differentiation
negative chemotaxis
semaphorin-plexin signaling pathway
regulation of postsynapse assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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