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Invitrogen
SKI Polyclonal Antibody
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Product Details
PA5-51253
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide of human SKI
Conjugate
Form
Liquid
Concentration
2.8 mg/mL
Amount
280 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total SKI protein.
Target Information
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Proto-oncogene c-Ski; Ski oncogene; ski oncoprotein; Sloan-Kettering Institute proto-oncogene; unnamed protein product; v-ski avian sarcoma viral oncogene homolog
Gene Aliases: SGS; SKI; SKV
UniProt ID: (Human) P12755
Entrez Gene ID: (Human) 6497
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
zinc ion binding
protein kinase binding
protein domain specific binding
ubiquitin protein ligase binding
identical protein binding
SMAD binding
histone deacetylase inhibitor activity
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
neural tube closure
lens morphogenesis in camera-type eye
transforming growth factor beta receptor signaling pathway
negative regulation of cell proliferation
anterior/posterior axis specification
negative regulation of Schwann cell proliferation
myotube differentiation
olfactory bulb development
myelination in peripheral nervous system
positive regulation of Wnt signaling pathway
embryonic limb morphogenesis
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
negative regulation of activin receptor signaling pathway
somatic stem cell population maintenance
camera-type eye development
positive regulation of DNA binding
nose morphogenesis
negative regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast proliferation
camera-type eye morphogenesis
skeletal muscle fiber development
cell motility
regulation of neurogenesis
palate development
cardiac muscle cell proliferation
retina development in camera-type eye
face morphogenesis
bone morphogenesis
negative regulation of SMAD protein import into nucleus
muscle structure development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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