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Invitrogen
CARD8 Polyclonal Antibody
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Product Details
PA5-60397
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CARD8. Recombinant protein control fragment (Product #RP-98956).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PITSNTLIYY HPHPEDIKFH LYLVPSDALL TKAIDDEEDR FHGVRLQTSP PMEPLNFGSS YIVSNSANLK VMPKELKLSY RSPGEIQHFS KFYAGQMK
Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 55%.
Target Information
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo-ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappa-B activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptotic protein NDPP1; CARD 8; CARD inhibitor of NF-kappaB-activating ligands; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; CARDINAL; CARD family adaptor protein; Caspase recruitment domain-containing protein 8; DKFZp779L0366; KI; TUCAN; Tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine; unnamed protein product
Gene Aliases: CARD8; CARDINAL; DACAR; DAKAR; KIAA0955; NDPP; NDPP1; TUCAN
UniProt ID: (Human) Q9Y2G2
Entrez Gene ID: (Human) 22900
activation of innate immune response
immune system process
proteolysis
inflammatory response
negative regulation of tumor necrosis factor-mediated signaling pathway
programmed cell death
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of interleukin-1 beta production
positive regulation of interleukin-1 beta production
regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of inflammatory response
protein homooligomerization
protein maturation
defense response to virus
pyroptosis
intrinsic apoptotic signaling pathway
self proteolysis
antiviral innate immune response
CARD8 inflammasome complex assembly
pyroptotic cell death
negative regulation of NLRP3 inflammasome complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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