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Immunogen sequence: LNPTFIPPPYG VLRSLLENPL KLPLHHEDAF SKDKDKEKKL DDESNSPTVP QSAFLGPTLW DKTLPYDGDT F
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 94%.
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Hepatic leukemia factor; PAR bZIP transcription factor
Gene Aliases: HLF
UniProt ID: (Human) Q16534
Entrez Gene ID: (Human) 3131
Molecular Function: basic leucine zipper transcription factor
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