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Invitrogen
ATP6V0A1 Polyclonal Antibody
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FIGURE: 1 / 1
ATP6V0A1 Antibody (PA5-68830) in ICC/IF
Immunocytochemistry was performed on HeLa tissue using a ATP6V0A1 polyclonal primary antibody (Product # PA5-68830) with a dilution of 1:250, anti-rabbit Alexa Fluor 488 with a secondary antibody dilution of 1:1000 and Atp6v0a1 (green) and DAPI (blue).
Product Details
PA5-68830
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide corresponding to a region of mouse ATP6V0A1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 100%; Horse: 93%; Human: 86%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%
Target Information
ATP6V0A1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenosine triphosphatase; ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1A (110/160 kDa); ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); ATPase, H+ transporting, lysosomal V0 subunit a; ATPase, H+ transporting, lysosomal V0 subunit a1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; unnamed protein product; V-A; V-ATPase 116 kDa; V-ATPase 116 kDa subunit a 1; V-ATPase 116 kDa subunit a1; V-ATPase a1; V-ATPase subunit a1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 1; V-type proton ATPase 116 kDa subunit a isoform 1; V-type proton ATPase 116 kDa subunit a1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1; vacuolar-type H(+)-ATPase 115 kDa subunit
Gene Aliases: a1; AA959968; ATP6a1; ATP6N1; ATP6N1A; ATP6V0A1; Atpv0a1; DEE104; NEDEBA; Stv1; Vph1; Vpp-1; VPP1
UniProt ID: (Human) Q93050, (Mouse) Q9Z1G4
Entrez Gene ID: (Human) 535, (Mouse) 11975
ion transport
vacuolar acidification
lysosomal lumen acidification
regulation of macroautophagy
endosomal lumen acidification
synaptic vesicle lumen acidification
hydrogen ion transmembrane transport
transport
ATP synthesis coupled proton transport
ATP hydrolysis coupled proton transport
proton transport
vacuolar proton-transporting V-type ATPase complex assembly
toxin transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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