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Invitrogen
Ubiquitin B Polyclonal Antibody
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Product Details
PA5-70602
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human Ubiquitin B
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Yeast: 100%; Zebrafish: 100%
Target Information
Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory protein Li 50; HUBCEP52; MGC127041; polyubiquitin B; Polyubiquitin-B; RPL40; unnamed protein product
Gene Aliases: AL033289; HEL-S-50; Rps27a; Uba52; UBB; Ubb2; Ubc
UniProt ID: (Human) P0CG47, (Mouse) P0CG49
Entrez Gene ID: (Human) 7314, (Mouse) 22187
male meiosis I
female meiosis I
male gonad development
female gonad development
ubiquitin homeostasis
hypothalamus gonadotrophin-releasing hormone neuron development
mitochondrion transport along microtubule
neuron projection morphogenesis
regulation of mitochondrial membrane potential
adipose tissue development
fat pad development
regulation of proteasomal protein catabolic process
seminiferous tubule development
energy homeostasis
regulation of neuron death
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
protein ubiquitination
modification-dependent protein catabolic process
positive regulation of protein ubiquitination
regulation of neuron apoptotic process
positive regulation of protein monoubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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