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Invitrogen
HTR3A Polyclonal Antibody
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Product Details
PA5-75299
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 150-200 of Human HTR3A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-3; 5-HT3 receptor; 5-HT3-A; 5-HT3A; 5-HT3R; 5-HT3R-As; 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic; 5-hydroxytryptamine receptor 3; 5-hydroxytryptamine receptor 3A; 5HT3 serotonin receptor; serotonin receptor; Serotonin receptor 3A; Serotonin-gated ion channel receptor; truncated receptor; unnamed protein product
Gene Aliases: 5-HT-3; 5-HT3; 5-HT3A; 5-HT3R; 5HT3; 5HT3R; HTR3; HTR3A
UniProt ID: (Human) P46098, (Rat) P35563, (Mouse) P23979
Entrez Gene ID: (Human) 3359, (Rat) 79246, (Mouse) 15561
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
protein binding
ligand-gated ion channel activity
serotonin-gated cation channel activity
identical protein binding
serotonin binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
G-protein coupled serotonin receptor activity
serotonin-activated cation-selective channel activity
voltage-gated potassium channel activity
ligand-gated ion channel
ion transport
serotonin receptor signaling pathway
chemical synaptic transmission
ion transmembrane transport
regulation of membrane potential
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
inorganic cation transmembrane transport
regulation of presynaptic membrane potential
serotonin-gated cation-selective signaling pathway
cation transport
response to cocaine
response to ethanol
cellular response to growth factor stimulus
potassium ion transmembrane transport
cation transmembrane transport
transport
regulation of ion transmembrane transport
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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