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Invitrogen
CARD14 Polyclonal Antibody
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Product Details
PA5-75827
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human CARD14.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase. CARD 14 is expressed in the placenta where it positively regulates apoptosis. CARD 14 also controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex. Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bcl10-interacting MAGUK protein 2; Bimp2; CARD-containing MAGUK protein 2; CARD14; CARD/MAGUK family member; Carma 2; caspase recruitment domain family, member 14; Caspase recruitment domain-containing protein 14; scaffold protein; unnamed protein product
Gene Aliases: BIMP2; CARD14; CARMA2; PRP; PSORS2; PSS1
UniProt ID: (Human) Q9BXL6, (Mouse) Q99KF0
Entrez Gene ID: (Human) 79092, (Mouse) 170720, (Rat) 688292
positive regulation of protein phosphorylation
apoptotic process
tumor necrosis factor-mediated signaling pathway
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of NF-kappaB transcription factor activity
activation of NF-kappaB-inducing kinase activity
positive regulation of macromolecule metabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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