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Invitrogen
RHD Polyclonal Antibody
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FIGURE: 1 / 1
RHD Antibody (PA5-75922) in WB
Western blot analysis of RHD in Lane 1: the Brain tissue lysate of rat (30 µg), Lane 2: the Brain tissue lysate of mouse (30 µg), Lane 3: HEK293T whole cell lysate (40 µg), Lane 4: H9C2 whole cell lysate (40 µg). Samples were incubated with RHD polyclonal antibody (Product # PA5-75922) at a dilution of 1:500.
Product Details
PA5-75922
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 168-213 of Human RHD.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The Rhesus (Rh) blood group system represents one of the most complex and important systems in humans. Two highly homologous genes RHD and RHCE (collectively referred to as RH30 or RHCED) encode the antigens of the Rh blood group system (1-4). These tightly linked genes map to human chromosomal position 1p34.1-1p36. The RHD gene, which is commonly deleted from a large segment of the population, encodes the most potent blood group immunogen, the D antigen (2,5). Rh incompatibility between maternal and fetal blood types results in hemolytic disease of the newborn (HDN), which often results in fetal death (1,2,6). The RHCE gene exists in four allelic forms, and each allele determines the expression of two antigens in Ce, ce, cE, or CE combinations (2,4,5). The RHCED antigens exist as integral membrane proteins with contain 12-transmembrane helices, and maintain erythrocyte membrane integrity. The presentation of the Rh antigenic activity requires the formation of a complex between the RHCED antigens and RHAG (RH50).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: blood group antigen D; blood group protein RHD; Blood group Rh(D) polypeptide; CD240D; D antigen (DCS); Del(L18P) protein; Erythrocyte membrane glycoprotein Rh30; mutation in the fifth exon with base deletions and insertion of T and C bases; Rh blood group antigen Evans; Rh blood group C antigen; Rh blood group CcEe antigen; Rh blood group D antigen weak D type 160; Rh blood group protein; Rh blood group system D-antigen; Rh blood group, D anitgen; RH polypeptide 2; Rh polypeptide II; Rh(D) Blood-Group antigen; Rh-like polypeptide; RHD; RhD antigen; RhD blood group antigen; RhD glycoprotein; RhD polypeptide; RhD protein; RHDVI type IV variant; Rhesus blood group antigen D; Rhesus blood group CE and D; Rhesus D antigen; Rhesus D blood group protein; Rhesus system D polypeptide; Rhesus system D polypeptide; RH polypeptide 2; blood group Rh(D) polypeptide; D antigen (DCS); Rh blood group antigen Evans; rhesus D antigen; RhPII; RHXIII; unnamed protein product; weak D; weak RHD antigen
Gene Aliases: CD240D; DIIIc; HDFNRH; RH; RH30; Rh4; RHCED; RHD; RhDCw; RHDel; RHDVA(TT); RhII; RhK562-II; Rhl1; RhPI; RHPII; RHXIII; SLC42A5
UniProt ID: (Human) Q02161, (Mouse) Q8CF94, (Rat) O88298
Entrez Gene ID: (Human) 6007, (Mouse) 19746, (Rat) 60414
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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