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Invitrogen
MAPK15 Polyclonal Antibody
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FIGURE: 1 / 1
MAPK15 Antibody (PA5-75930) in WB
Western blot analysis of MAPK15 in Lane 1: HeLa whole cell lysate (51.3 µg), Lane 2: the Lung tissue lysate of rat (39.4 µg), Lane 3: the Lung tissue lysate of mouse (39.4 µg), Lane 4: A549 whole cell lysate (57.6 µg). Samples were incubated with MAPK15 polyclonal antibody (Product # PA5-75930) at a dilution of 1:1,000.
Product Details
PA5-75930
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 351-396 of Human MAPK15.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 2.7.11.24; ERK-7; ERK-8; ERK8 delta; protein kinase; MAP kinase family protein; extracellular regulated kinase 8 delta; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15; Mitogen-activated protein kinase 15
Gene Aliases: BC048082; ERK7; ERK8; MAPK15
UniProt ID: (Human) Q8TD08, (Rat) Q9Z2A6, (Mouse) Q80Y86
Entrez Gene ID: (Human) 225689, (Rat) 286997, (Mouse) 332110
nucleotide binding
chromatin binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
kinase activity
transferase activity
SH3 domain binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
regulation of COPII vesicle coating
cellular response to DNA damage stimulus
endoplasmic reticulum organization
positive regulation of cell proliferation
regulation of autophagy
negative regulation of cell migration
positive regulation of telomere maintenance
cellular response to stress
intracellular signal transduction
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
dopamine uptake
regulation of cilium assembly
protein localization to ciliary transition zone
positive regulation of metaphase/anaphase transition of meiosis I
positive regulation of spindle assembly
negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein phosphorylation
protein phosphorylation
negative regulation of DNA replication
positive regulation of protein ubiquitination
response to estradiol
positive regulation of protein catabolic process
phosphorylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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