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Invitrogen
GPIP137 Polyclonal Antibody
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Product Details
PA5-76298
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human CAPRIN1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
GPIP137 regulates the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation/migration in multiple cell types. It binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, GPIP137 binds to several mRNAs associated with RNA granules including BDNF, CAMK2A, CREB1, MAP2, NTRK2, mRNAs, GRIN1, and KPNB1 mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activation/proliferation-associated protein 1; caprin 1; Caprin-1; Cell cycle-associated protein 1; cytop; Cytoplasmic activation- and proliferation-associated protein 1; cytoplasmic activation/proliferation-associated protein 1; cytoplasmic activation/proliferation-associated protein-1; GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; Membrane component chromosome 11 surface marker 1; p137GPI; RNA granule protein 105; unnamed protein product
Gene Aliases: AL022980; Caprin-1; CAPRIN1; CONDCAC; G5E5; GPI p137; Gpiap; GPIAP1; GPIP137; GRIP137; M11S1; Mmgpip137; NEDLAAD; P137; p137GPI; RNG105
UniProt ID: (Human) Q14444, (Mouse) Q60865, (Rat) Q5M9G3
Entrez Gene ID: (Human) 4076, (Mouse) 53872, (Rat) 362173
deadenylation-dependent decapping of nuclear-transcribed mRNA
nervous system development
synapse assembly
intracellular mRNA localization
negative regulation of translation
cell differentiation
stress granule assembly
negative regulation of translational initiation
generation of neurons
positive regulation of dendrite morphogenesis
synapse organization
positive regulation of dendritic spine morphogenesis
positive regulation of stress granule assembly
regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA
membraneless organelle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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