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Arginase 2 Polyclonal Antibody
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FIGURE: 1 / 5
Arginase 2 Antibody (PA5-78820) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Arginase 2 in paraffin-embedded section of human prostate cancer tissue using Arginase 2 Polyclonal Antibody (Product # PA5-78820). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL diluti... View More
Product Details
PA5-78820
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Arg2 (67-85aa DFGDLSFTPVPKDDLYNNL).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human 293T whole cell, human PC-3 whole cell, human K562 whole cell, human HepG2 whole cell. IHC: human prostate cancer tissue.
Target Information
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARG2; Arginase II; arginase, type II; Arginase-2, mitochondrial; kidney arginase; Kidney-type arginase; L-arginine amidinohydrolase; L-arginine ureahydrolase; Non-hepatic arginase; nonhepatic arginase; Type II arginase; unnamed protein product
Gene Aliases: ARG2
UniProt ID: (Human) P78540
Entrez Gene ID: (Human) 384
urea cycle
ureteric bud development
adaptive immune response
immune system process
negative regulation of type 2 immune response
arginine metabolic process
nitric oxide biosynthetic process
striated muscle contraction
regulation of interleukin-1 beta production
negative regulation of interleukin-13 production
negative regulation of interleukin-17 production
negative regulation of tumor necrosis factor production
innate immune response
negative regulation of multicellular organismal process
negative regulation of macrophage inflammatory protein 1 alpha production
negative regulation of chemokine (C-C motif) ligand 4 production
negative regulation of chemokine (C-C motif) ligand 5 production
negative regulation of defense response to bacterium
regulation of reactive oxygen species biosynthetic process
negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
negative regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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