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Invitrogen

PTPN22 Polyclonal Antibody

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PTPN22 Polyclonal Antibody

Product Details

PA5-79896

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

ELISA (ELISA)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived mouse PTPN22 recombinant protein (Position: M1-Q309).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2747011

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat thymus tissue, human SW579 whole cell, human HepG2 whole cell, human placenta tissue, human Hela whole cell, human SW620 whole cell. IHC: mouse spleen tissue, rat lymphaden tissue.

Target Information

The protein tyrosine phosphatase PTPN22 (PTP22, LYP, PEP, formerly PTPN8) is a genetic variant that confers risk of developing diverse human autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase also known as "Lyp." The risk allele is present in about 17% of Caucasian individuals from the general population and in approximately 28% of Caucasian individuals with rheumatoid arthritis; it is thought to disrupt the P1 proline-rich motif that is important for interaction with the Src homology-3 (SH3) domain of CSK (cytoplasmic tyrosine kinase), potentially altering the normal functions of these proteins as negative regulators of T cell activation. The interaction between CSK and PTPN22 is highly specific and it is speculated that PTPN22 may be an effector and/or regulator of CSK in T cells and other hematopoietic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; LYP3; PEP; PEST domain-enriched tyrosine phosphatase; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; PTPN22.8; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 22; unnamed protein product

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Gene Aliases: 70zpep; LYP; LYP1; LYP2; PEP; PTPN22; PTPN22.5; PTPN22.6; PTPN8

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UniProt ID: (Human) Q9Y2R2, (Mouse) P29352

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Entrez Gene ID: (Human) 26191, (Rat) 295338, (Mouse) 19260

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Function(s)
phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity SH3 domain binding kinase binding ubiquitin protein ligase binding molecular_function
Process(es)
immune system process lipid metabolic process autophagy negative regulation of autophagy positive regulation of gene expression negative regulation of gene expression T cell differentiation lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide negative regulation of interleukin-6 production negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production regulation of natural killer cell proliferation positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway phosphoanandamide dephosphorylation negative regulation of JUN kinase activity regulation of innate immune response T cell receptor signaling pathway regulation of B cell receptor signaling pathway regulation of T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of T cell activation positive regulation of ERK1 and ERK2 cascade negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to muramyl dipeptide positive regulation of NLRP3 inflammasome complex assembly regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked ubiquitination negative regulation of p38MAPK cascade protein dephosphorylation biological_process peptidyl-tyrosine dephosphorylation dephosphorylation
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