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Invitrogen
BRSK1 Polyclonal Antibody
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Product Details
PA5-84515
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BRSK1. Recombinant protein control fragment (Product #RP-103421).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VEPEKRLSLE QIQKHPWYLG GKHEPDPCLE PAPGRRVAMR SLPSNGELDP D
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
Target Information
BRSK1 (SAD1) is a serine/threonine kinase, and is a UV-induced DNA damage checkpoint kinase. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BR serine/threonine-protein kinase 1; Brain-selective kinase 1; Brain-specific serine/threonine-protein kinase 1; protein kinase SAD1A; SAD1 homolog; SAD1 kinase; SAD1A; Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog 1; unnamed protein product
Gene Aliases: BRSK1; hSAD1; KIAA1811; SAD-B; SAD1; SADB
UniProt ID: (Human) Q8TDC3
Entrez Gene ID: (Human) 84446
G2/M transition of mitotic cell cycle
protein phosphorylation
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
neurotransmitter secretion
nervous system development
axonogenesis
associative learning
response to UV
response to ionizing radiation
regulation of synaptic vesicle priming
regulation of neuron projection development
peptidyl-serine phosphorylation
central nervous system neuron differentiation
establishment of cell polarity
neuron differentiation
regulation of synaptic plasticity
neuron projection morphogenesis
regulation of axonogenesis
centrosome duplication
microtubule cytoskeleton organization involved in establishment of planar polarity
synaptic vesicle cycle
regulation of synaptic vesicle clustering
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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