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Invitrogen

HDAC3 Polyclonal Antibody

View all (35) HDAC3 antibodies

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Product Details

PA5-85378

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Immunoprecipitation (IP)

1:100-1:500
-

ChIP assay (ChIP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human HDAC3. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.32 mg/mL

Amount

32 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792520

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (89%), Pig (100%), Chicken (95%), Rhesus Monkey (100%), Bovine (100%).

Positive Control: 293T, A431, HeLa, HepG2, U87-MG, SK-N-SH, IMR32, SK-N-AS, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2, NB2a.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HD3; HDAC3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; Histone deacetylase 3; Protein deacetylase HDAC3; Protein deacylase HDAC3; RPD3-2; SMAP45

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Gene Aliases: AW537363; HD3; HDAC3; KDAC3; RPD3; RPD3-2; zgc:55927

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UniProt ID: (Human) O15379, (Mouse) O88895, (Rat) Q6P6W3, (Zebrafish) Q803C3

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Entrez Gene ID: (Human) 8841, (Mouse) 15183, (Rat) 84578, (Zebrafish) 393965

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Function(s)
transcription corepressor binding DNA binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding hydrolase activity deacetylase activity enzyme binding cyclin binding chromatin DNA binding protein deacetylase activity histone deacetylase binding GTPase binding NF-kappaB binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism protein decrotonylase activity histone decrotonylase activity protein de-2-hydroxyisobutyrylase activity protein lysine delactylase activity ubiquitin-specific protease binding transcription factor binding histone deacetylase activity (H3-K14 specific) NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific) metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of protein phosphorylation transcription, DNA-templated regulation of transcription, DNA-templated protein deacetylation regulation of mitotic cell cycle chromatin modification histone deacetylation regulation of protein stability positive regulation of TOR signaling negative regulation of interleukin-1 production negative regulation of tumor necrosis factor production circadian regulation of gene expression regulation of multicellular organism growth positive regulation of transcription factor import into nucleus negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of protein export from nucleus spindle assembly cellular response to fluid shear stress positive regulation of type B pancreatic cell apoptotic process negative regulation of cardiac muscle cell differentiation angiogenesis liver development chromatin organization dorsal/ventral pattern formation regulation of circadian rhythm rhythmic process posterior lateral line development histone H3 deacetylation histone H4 deacetylation negative regulation of myotube differentiation response to nutrient levels response to drug histone H3-K9 modification cellular response to mechanical stimulus cellular response to parathyroid hormone stimulus response to dexamethasone establishment of mitotic spindle orientation in utero embryonic development transcription from RNA polymerase II promoter epidermis development response to xenobiotic stimulus gene expression positive regulation of protein ubiquitination protein modification process regulation of gene expression, epigenetic positive regulation of protein import into nucleus negative regulation of apoptotic process random inactivation of X chromosome neural precursor cell proliferation establishment of skin barrier negative regulation of ferroptosis positive regulation of cold-induced thermogenesis DNA repair-dependent chromatin remodeling positive regulation of ferroptosis cornified envelope assembly
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