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Invitrogen
Ataxin 3 Polyclonal Antibody
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Product Details
PA5-88538
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.35 mg/mL
Amount
135 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: MCF7, SW480, Jurkat, A-549, DU145; Cellular Location: Nucleus matrix
Target Information
Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ataxin-3; ataxin3; josephin; Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog; Machado-Joseph disease protein 1; Machado-Joseph disease protein 1 homolog; olivopontocerebellar ataxia 3; spin; Spinocerebellar ataxia type 3 protein
Gene Aliases: 2210008M02Rik; AI463012; AI647473; AT3; ataxin-3; ATX3; ATXN3; JOS; MJD; MJD1; Rsca3; SCA3
UniProt ID: (Human) P54252, (Rat) O35815, (Mouse) Q9CVD2
Entrez Gene ID: (Human) 4287, (Rat) 60331, (Mouse) 110616
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
ubiquitin protein ligase binding
identical protein binding
ATPase binding
Lys63-specific deubiquitinase activity
Lys48-specific deubiquitinase activity
RNA polymerase II regulatory region DNA binding
histone deacetylase activity
omega peptidase activity
chromatin/chromatin-binding, or -regulatory protein
microtubule cytoskeleton organization
cytoplasmic translation
nucleotide-excision repair
proteolysis
ubiquitin-dependent protein catabolic process
misfolded or incompletely synthesized protein catabolic process
chemical synaptic transmission
nervous system development
cellular response to starvation
regulation of cell-substrate adhesion
protein deubiquitination
actin cytoskeleton organization
cellular response to nutrient levels
cellular response to amino acid starvation
cellular response to heat
monoubiquitinated protein deubiquitination
exploration behavior
TORC1 signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
intermediate filament cytoskeleton organization
negative regulation of translational initiation
positive regulation of translational initiation
protein K63-linked deubiquitination
protein K48-linked deubiquitination
cellular response to misfolded protein
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
positive regulation of ERAD pathway
protein localization to cytosolic proteasome complex
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
histone H3 deacetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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