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Invitrogen
NQO1 Polyclonal Antibody
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Product Details
PA5-90277
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human NQO1 (NP_0008941)
Conjugate
Form
Liquid
Concentration
0.87 mg/mL
Amount
87 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: A-549, HT-29; Cellular Location: Cytoplasm
Immunogen sequence: MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QFPLQWFGVP AILKGWFERV FIGEFAYTYA AMYDKGPFRS KKAVLSITTG GSGSMYSLQG IHGDMNVILW PIQSGILHFC GFQVLEPQLT YSIGHTPADA RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK KEVQDEEKNK KFGLSVGHHL GKSIPTDNQI KARK
Target Information
NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Altered expression of the protein has been seen in many tumors and is also associated with Alzheimer's disease (AD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Azoreductase; Diaphorase (NADH/NADPH); diaphorase (NADH/NADPH) (cytochrome b-5 reductase); Diaphorase 4; diaphorase 4 (NADH/NADPH); diaphorase-4; dioxin-inducible 1; DT-diaphorase; DTD; Menadione reductase; NAD(P)H dehydrogenase (quinone); NAD(P)H dehydrogenase [quinone] 1; NAD(P)H dehydrogenase, quinone 1; NAD(P)H menadione oxidoreductase 1, dioxin inducible; NAD(P)H-quinone oxidoreductase; NAD(P)H:menadione oxidoreductase; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:quinone oxireductase; NQ01; Phylloquinone reductase; QR1; Quinone reductase 1; unnamed protein product
Gene Aliases: AV001255; DHQU; DIA4; DTD; Nmo-1; Nmo1; NMOR1; NMORI; NQO1; Ox-1; Ox1; QR1
UniProt ID: (Human) P15559, (Mouse) Q64669, (Rat) P05982
Entrez Gene ID: (Human) 1728, (Mouse) 18104, (Rat) 24314
RNA binding
NAD(P)H dehydrogenase (quinone) activity
cytochrome-b5 reductase activity, acting on NAD(P)H
protein binding
NADPH dehydrogenase (quinone) activity
oxidoreductase activity
identical protein binding
NADH dehydrogenase (quinone) activity
superoxide dismutase activity
poly(A) RNA binding
oxidoreductase
protein polyubiquitination
ubiquinone metabolic process
xenobiotic metabolic process
nitric oxide biosynthetic process
response to oxidative stress
synaptic transmission, cholinergic
response to toxic substance
removal of superoxide radicals
protein catabolic process
response to lipopolysaccharide
cellular response to oxidative stress
negative regulation of protein catabolic process
vitamin E metabolic process
vitamin K metabolic process
innate immune response
cell redox homeostasis
response to caloric restriction
negative regulation of ferroptosis
superoxide metabolic process
negative regulation of catalytic activity
positive regulation of neuron apoptotic process
oxidation-reduction process
aging
response to nutrient
response to organic cyclic compound
response to estradiol
response to ethanol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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