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Invitrogen
CD9 Polyclonal Antibody
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FIGURE: 1 / 2
CD9 Antibody (PA5-95868) in IHC (P)
Immunohistochemistry analysis of CD9 in paraffin-embedded human smooth muscle. Samples were incubated with CD9 Polyclonal antibody (Product # PA5-95868) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-95868
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 112-195 of human CD9 (NP_0017601)
Conjugate
Form
Liquid
Concentration
7.19 mg/mL
Amount
719 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SHKDEVIKEV QEFYKDTYNK LKTKDEPQRE TLKAIHYALN CCGLAGGVEQ FISDICPKKD VLETFTVKSC PDAIKEVFDN KFHI; Positive Samples: Mouse kidney; Cellular Location: Cell membrane, Membrane, Multi-pass membrane protein
Target Information
CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5H9; 5H9 antigen; antigen CD9; BA-2/p24 antigen; BA2; BTCC-1p; CD9; CD9 antigen; CD9 antigen (p24); Cell growth-inhibiting gene 2 protein; GIG2; Leukocyte antigen MIC3; motility related protein-1; Motility-related protein; MRP-1; p24; sCD 9; sCD9; soluble CD 9; soluble CD9; Tetraspanin-29; Tetraspanin29; Tspan-29; unnamed protein product
Gene Aliases: BTCC-1; CD9; DRAP-27; GIG2; MIC3; MRP-1; TSPAN-29; TSPAN29
UniProt ID: (Human) P21926, (Mouse) P40240, (Rat) P40241
Entrez Gene ID: (Human) 928, (Mouse) 12527, (Rat) 24936
movement of cell or subcellular component
cell adhesion
single fertilization
fusion of sperm to egg plasma membrane
negative regulation of cell proliferation
paranodal junction assembly
brain development
response to water deprivation
oligodendrocyte development
nervous system development
cell proliferation
glial cell migration
myoblast fusion involved in skeletal muscle regeneration
cell differentiation
platelet activation
receptor internalization
sperm-egg recognition
cellular response to low-density lipoprotein particle stimulus
negative regulation of platelet aggregation
regulation of macrophage migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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