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Invitrogen

EGR1 Polyclonal Antibody

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EGR1 Polyclonal Antibody

Product Details

PA5-99273

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human EGR1(Accession P18146), corresponding to amino acid residues S441-P461.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818206

Product Specific Information

Antibody detects endogenous levels of total EGR1.

Target Information

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AT225; Early growth response protein 1; EGR-1; ETR103; Krox-24 nuclear protein; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; unnamed protein product; zinc finger gene 225; Zinc finger protein 225; Zinc finger protein Krox-24

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Gene Aliases: A530045N19Rik; AT225; egr; Egr-1; EGR1; ETR103; G0S30; Krox-1; KROX-24; KROX24; NGF1-A; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6; ZIF-268; ZIF268; ZNF225

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UniProt ID: (Human) P18146, (Mouse) P08046

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Entrez Gene ID: (Human) 1958, (Mouse) 13653

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding double-stranded methylated DNA binding enzyme binding histone acetyltransferase binding sequence-specific DNA binding hemi-methylated DNA-binding metal ion binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding nucleic acid binding double-stranded DNA binding transcription factor binding transcription regulatory region DNA binding C2H2 zinc finger transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia response to ischemia regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter response to glucose positive regulation of gene expression T cell differentiation BMP signaling pathway positive regulation of chemokine production positive regulation of interleukin-1 beta production response to insulin circadian regulation of gene expression regulation of protein sumoylation skeletal muscle cell differentiation regulation of apoptotic process regulation of neuron apoptotic process hypomethylation of CpG island estrous cycle locomotor rhythm positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone biosynthetic process rhythmic process circadian temperature homeostasis interleukin-1-mediated signaling pathway cellular response to gamma radiation cellular response to heparin cellular response to mycophenolic acid glomerular mesangial cell proliferation positive regulation of glomerular metanephric mesangial cell proliferation negative regulation of canonical Wnt signaling pathway cellular response to interleukin-8 positive regulation of post-translational protein modification positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of progesterone biosynthetic process transcription, DNA-templated transcription from RNA polymerase II promoter learning or memory positive regulation of cell death negative regulation of apoptotic process positive regulation of neuron apoptotic process regulation of long-term neuronal synaptic plasticity regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to organic substance cellular response to cAMP cellular response to gonadotropin stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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