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Invitrogen

Phospho-Annexin A2 (Ser26) Polyclonal Antibody

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Phospho-Annexin A2 (Ser26) Polyclonal Antibody

Product Details

PA5-99479

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ANXA2(Accession P07355), corresponding to amino acid residues around phosphorylated Ser26.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818412

Product Specific Information

Antibody detects endogenous levels of Annexin A2 only when phosphorylated at Ser26.

Target Information

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 33-kDa calcimedin; 33-kDa lymphocyte Ca<2+>- binding protein; 33kDa lymphocyte Ca<2+>- binding protein; 36-kDa calelectrin; Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; epididymis secretory protein Li 270; epididymis secretory sperm binding protein; Lipocortin II; p36; PAP-IV; Placental anticoagulant protein IV; Protein I; unnamed protein product

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Gene Aliases: ANX2; ANX2L4; ANXA2; AW215814; CAL1H; HEL-S-270; LIP2; LPC2; LPC2D; P36; PAP-IV

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UniProt ID: (Human) P07355, (Mouse) P07356, (Rat) Q07936

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Entrez Gene ID: (Human) 302, (Mouse) 12306, (Rat) 56611

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Function(s)
phosphatidylserine binding protease binding RNA binding phospholipase inhibitor activity serine-type endopeptidase inhibitor activity calcium ion binding protein binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding cytoskeletal protein binding phospholipase A2 inhibitor activity identical protein binding S100 protein binding calcium-dependent protein binding cadherin binding involved in cell-cell adhesion Rab GTPase binding receptor activator activity poly(A) RNA binding actin filament binding calcium-binding protein
Process(es)
angiogenesis membrane raft assembly positive regulation of receptor recycling negative regulation of receptor internalization membrane budding cell adhesion cell-matrix adhesion positive regulation of plasminogen activation response to activity collagen fibril organization lung development positive regulation of vesicle fusion negative regulation of low-density lipoprotein particle receptor catabolic process osteoclast development fibrinolysis mRNA transcription from RNA polymerase II promoter positive regulation of vacuole organization positive regulation of exocytosis positive regulation of transcription from RNA polymerase II promoter regulation of neurogenesis negative regulation of transport positive regulation of multicellular organismal process cell-cell adhesion epithelial cell apoptotic process positive regulation of low-density lipoprotein particle clearance positive regulation of receptor-mediated endocytosis involved in cholesterol transport positive regulation of plasma membrane repair positive regulation of protein phosphorylation body fluid secretion negative regulation of catalytic activity positive regulation of fibroblast proliferation positive regulation of binding protein heterotetramerization cellular response to acid chemical protein targeting to plasma membrane negative regulation of receptor binding positive regulation of receptor activity regulation of fibrinolysis
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