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Invitrogen
Phospho-Caspase 6 (Ser257) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-Caspase 6 (Ser257) Antibody (PA5-12557) in IHC (P)
Immunohistochemistry analysis of Phospho-Caspase 6 (Ser257) in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with Phospho-Caspase 6 (Ser257) polyclonal antibody (Product # PA5-12557) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been e... View More
Product Details
PA5-12557
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S257 of human Caspase 6
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, mouse and rat based on sequence homology.
Target Information
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptotic protease Mch-2; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; mammalian Ced-3 homologue 2; mCASP-6
Gene Aliases: CASP6; caspase-6; CSP-6; MCH2
UniProt ID: (Human) P55212
Entrez Gene ID: (Human) 839
activation of innate immune response
proteolysis
apoptotic process
protein autoprocessing
epithelial cell differentiation
positive regulation of apoptotic process
regulation of programmed cell death
positive regulation of neuron apoptotic process
protein maturation
positive regulation of necroptotic process
pyroptosis
intrinsic apoptotic signaling pathway by p53 class mediator
cellular response to staurosporine
positive regulation of release of cytochrome c from mitochondria
hepatocyte apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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