Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Recommended positive controls: HCT116 cells.
Predicted reactivity: Mouse (94%), Rat (94%), Zebrafish (83%), Xenopus laevis (91%), Chicken (94%), Chimpanzee (100%), Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CSN12-like protein; PCI domain-containing protein 2; RP11-98F14.6
Gene Aliases: F10; HT004; PCID2
UniProt ID: (Human) Q5JVF3
Entrez Gene ID: (Human) 55795
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