Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
14960-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 2 publications 2 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PABPC4 Fusion Protein Ag6813 (285-631 aa encoded by BC065540) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.33 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: QERISRYQG VNLYIKNLDD TIDDEKLRKE FSPFGSITSA KVMLEDGRSK GFGFVCFSSP EEATKAVTEM NGRIVGSKPL YVALAQRKEE RKAHLTNQYM QRVAGMRALP ANAILNQFQP AAGGYFVPAV PQAQGRPPYY TPNQLAQMRP NPRWQQGGRP QGFQGMPSAI RQSGPRPTLR HLAPTGNAPA SRGLPTTTQR VGVPTAVQNL APRAAVAAAA PRAVAPYKYA SSVRSPHPAI QPLQAPQPAV HVQGQEPLTA SMLAAAPPQE QKQMLGERLF PLIQTMHSNL AGKITGMLLE IDNSELLHML ESPESLRSKV DEAVAVLQAH HAKKEAAQKV GAVAAATS (285-631 aa encoded by BC065540)
Target Information
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Activated-platelet protein 1; APP-1; Inducible poly(A)-binding protein; iPABP; PABP-4; poly(A) binding protein, cytoplasmic 4 (inducible form); poly(A)-binding protein 4; Polyadenylate-binding protein 4
Gene Aliases: APP-1; APP1; iPABP; PABP4; PABPC4
UniProt ID: (Human) Q13310
Entrez Gene ID: (Human) 8761, (Rat) 298510, (Mouse) 230721
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support