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7TM Antibodies
PAC1, PACAP Receptor 1 Polyclonal Antibody
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FIGURE: 1 / 7
PAC1, PACAP Receptor 1 Antibody (7TM0370N-IC) in IHC (P)
Immunohistochemical identification of PACAP Receptor 1 in human neuroendocrine tumor. Brain sections were dewaxed, microwaved in citric acid, and incubated with anti-PAC1 (PACAP Receptor 1) antibody (7TM0370N-IC) at a dilution of 1:100. Sections were then sequentially treated with biotinylated anti-rabbit IgG and avidin-biotin solution. Sections were then developed in 3, 3-diaminobenzidine (DAB)-glucose oxi... View More
Product Details
7TM0370N-IC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide presents distal end of carboxyl - terminal tail of human PAC1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined. PACAP receptor type 1 expression has been documented in adipose, adrenal, bone, brain, colon, ganglion, heart, lung, ovary, pancreas, placenta, spleen, and uterus. ESTs have been isolated from brain and nerve libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADCYAP1 R1; ADCYAP1R 1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; G-protein coupled receptor; PAC 1; PAC1 receptor; Pac1 receptors; PACAP R 1; PACAP Receptor; PACAP receptor 1; PACAP type I receptor; PACAP-R1; PACAP/VIP receptors; PACAP1 R; PACAP1 receptor; pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop; pituitary adenylate cyclase-activating polypeptide type 1 receptor; Pituitary adenylate cyclase-activating polypeptide type I receptor; pvr1; unnamed protein product
Gene Aliases: ADCYAP1R1; PAC1; PAC1R; PACAPR; PACAPRI
UniProt ID: (Human) P41586
Entrez Gene ID: (Human) 117
pituitary adenylate cyclase-activating polypeptide receptor activity
transmembrane signaling receptor activity
G-protein coupled receptor activity
vasoactive intestinal polypeptide receptor activity
protein binding
adenylate cyclase binding
G-protein coupled peptide receptor activity
peptide hormone binding
small GTPase binding
signaling receptor activity
neuropeptide binding
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
spermatogenesis
response to xenobiotic stimulus
positive regulation of calcium ion transport into cytosol
cell differentiation
response to estradiol
multicellular organismal response to stress
response to ethanol
development of primary female sexual characteristics
positive regulation of small GTPase mediated signal transduction
positive regulation of inositol phosphate biosynthetic process
cAMP/PKA signal transduction
positive regulation of cAMP/PKA signal transduction
negative regulation of response to reactive oxygen species
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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