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Bioss

PACAP-27/38 Polyclonal Antibody

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Product Details

BS-0190R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human PACAP-27/38, amino acids 132-169.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

PACAP 27/38 refers to the two biologically active isoforms of pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide derived from the ADCYAP1 gene through proteolytic processing of a larger precursor protein. PACAP-38 is the predominant endogenous form, while PACAP-27 corresponds to the N-terminal 27 amino acids of PACAP-38. Both peptides function as potent signaling molecules that bind to PAC1, VPAC1, and VPAC2 receptors, activating adenylate cyclase and downstream cAMP-dependent pathways. PACAP-27/38 plays important roles in neurodevelopment, neurotransmission, neuroprotection, stress response, circadian regulation, and modulation of immune and endocrine functions. Due to their broad physiological activity and involvement in neurological, inflammatory, and metabolic disorders, PACAP isoforms are widely studied in both basic and translational research contexts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenylate cyclase activating polypeptide 1 (pituitary); PACAP; PACAP 27; PACAP 28; pituitary adenylate cyclase activating polypeptide 1; Pituitary adenylate cyclase-activating polypeptide; pituitary adenylate cyclase-activating polypeptide precursor (Pacap); prepro-PACAP; unnamed protein product

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Gene Aliases: ADCYAP1; PACAP

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UniProt ID: (Human) P18509, (Rat) P13589, (Mouse) O70176

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Entrez Gene ID: (Human) 116, (Rat) 24166, (Mouse) 11516

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Function(s)
receptor binding hormone activity neuropeptide hormone activity protein binding pituitary adenylate cyclase activating polypeptide activity type 1 vasoactive intestinal polypeptide receptor binding type 2 vasoactive intestinal polypeptide receptor binding peptide hormone receptor binding receptor signaling protein activity pituitary adenylate cyclase-activating polypeptide receptor binding neuropeptide
Process(es)
adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway cell-cell signaling nervous system development female pregnancy regulation of G-protein coupled receptor protein signaling pathway positive regulation of gene expression insulin secretion neuron projection development regulation of protein localization positive regulation of GTPase activity negative regulation of cell cycle positive regulation of protein kinase activity positive regulation of transcription from RNA polymerase II promoter positive regulation of growth hormone secretion positive regulation of ERK1 and ERK2 cascade positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of cold-induced thermogenesis positive regulation of cAMP/PKA signal transduction ovarian follicle development behavioral fear response histamine secretion negative regulation of acute inflammatory response to antigenic stimulus negative regulation of acute inflammatory response to non-antigenic stimulus positive regulation of cell proliferation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway negative regulation of muscle cell apoptotic process positive regulation of neuron projection development sensory perception of pain cAMP-mediated signaling pituitary gland development positive regulation of cAMP biosynthetic process positive regulation of interleukin-6 production negative regulation of GTPase activity intracellular signal transduction response to starvation negative regulation of potassium ion transport response to ethanol positive regulation of vasodilation ATP metabolic process positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential negative regulation of glial cell proliferation regulation of oligodendrocyte progenitor proliferation cellular response to glucocorticoid stimulus positive regulation of somatostatin secretion
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