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PACRG Antibody (PA5-110069) in WB
Western blot analysis of PACRG in extracts of various cell lines. Samples were incubated with PACRG Polyclonal antibody (Product # PA5-110069) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-110069
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human PACRG (NP_001073847.1).
Conjugate
Form
Liquid
Concentration
1.62 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855480
Product Specific Information
Immunogen sequence: IIPIKNALNL RNRQVICVTL KVLQHLVVSA EMVGKALVPY YRQILPVLNI FKNMNVNSGD GIDYSQQKRE NIGDLIQETL EAFERYGGEN AFINIKYVVP T
Target Information
PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ32724; Hypertension-related protein 1-like protein; Molecular chaperone/chaperonin-binding protein; PARK2 co-regulated; PARK2 coregulated gene protein; parkin co-regulated gene protein; Parkin coregulated gene protein; Parkin coregulated gene protein homolog; RP3-495O10.2
Gene Aliases: 1700008H23Rik; GLUP; HAK005771; PACRG; PARK2CRG; RGD1561027
UniProt ID: (Human) Q96M98, (Mouse) Q9DAK2
Entrez Gene ID: (Human) 135138, (Mouse) 69310, (Rat) 499021
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